|
KMID : 0616120090400030229
|
|
Korean Journal of Pharmacognosy
2009 Volume.40 No. 3 p.229 ~ p.232
|
|
|
Alpha-glucosidase Inhibitors from the Branches Extract of Cotinus coggygria
|
|
Cha Mi-Ran
Park Jee-Hee
Choi Yeon-Hee
Choi Chun-Whan
Hong Kyung-Sik
Choi Sang-Un
Kim Young-Sup
Kim Young-Kyoon
Kim Young-Ho
Ryu Shi-Yong
|
|
|
Abstract
|
|
|
The ethanol (EtOH) extract of the branches of Cotinus coggygria (Anacardiaceae) exhibited a significant inhibition on the yeast α-glucosidase, one of the key enzymes related with diabetes mellitus, in a dose dependent manner, in vitro. The
intensive phytochemical survey of the EtOH extract of the species by way of bioactivity-guided fractionation resulted in the
isolation of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (1) as an active principle responsible for the inhibition on αglucosidase,
together with two related components 2 and 3. Compound 1 demonstrated a strong inhibition on the yeast α-glucosidase, in vitro and IC50 value was calculated as 0.96 mg/ml, when that of a reference drug, acarbose was estimated as 5.3 mg/ml. On the other hand, other related constituents of the species, 1,2,3,6-tetra-O-galloyl-β-D-glucose (2) and gallic acid (3) were exhibited relatively poor inhibition upon the yeast α-glucosidase, respectively.
|
|
|
KEYWORD
|
|
|
Cotinus coggygria, α-glucosidase, pentagalloylglucose, tannin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|